Tissue-dependent paired expression of miRNAs

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Tissue-dependent paired expression of miRNAs

It is believed that depending on the thermodynamic stability of the 5'-strand and the 3'-strand in the stem-loop structure of a precursor microRNA (pre-miRNA), cells preferentially select the less stable one (called the miRNA or guide strand) and destroy the other one (called the miRNA* or passenger strand). However, our expression profiling analyses revealed that both strands could be co-accum...

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ژورنال

عنوان ژورنال: Nucleic Acids Research

سال: 2007

ISSN: 1362-4962,0305-1048

DOI: 10.1093/nar/gkm641